Evaluation of Plasma Levels of Interferon-Gamma, Interleukin-6, and Transforming Growth Factor-Beta in Under-Five Children with Malaria Parasitaemia

BACKGROUND: The interaction between the pro- and anti-inflammatory cytokines is known to play key roles in immune response infectious diseases. pathogenesis of malaria parasitemia, including its progression symptomatic manifestation, also seems be strongly related this interplay. AIM: study evaluated plasma levels interferon-gamma (IFN-γ) interleukin-6 (IL)-6, which are inflammatory cytokines, transforming growth factor-beta (TGF-β), an cytokine; 6–60 months age-group children, when infected with Plasmodium falciparum, show their relevance development immunity against malaria. METHODS: was a cross-sectional involving children uncomplicated parasitemia. In study, parasitemia confirmed by microscopy, using Giemsa stain. enzyme-linked immunosorbent assay (ELISA) method used evaluate IFN-γ, IL-6, TGF-β under-five P. counterparts who were not parasite. RESULTS: median participants 225.15 pg/ mL, 123.31 pg/mL, 2091.02 respectively. difference uninfected statistically significant p < 0.001. CONCLUSION: findings work showed that associated depression level compared counterparts.